Ψ KRT37 - Vicugna pacos
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_IJSN1L | Vicugna pacos | Gene deletion | Full | No | Genomic & Synteny maps |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Hair follicle-specific keratin genes consisted of 9 hair follicle-specific epithelial keratin genes (K71-K75, K25-K28) and 17 hair keratins (K31-K40, K81-K86) expressed in hair follicle and hair which could directly affect hair growth." | 10.1186/s12983-017-0225-x |
| Methodology & Validation | "We first identified α-keratin gene repertoires in the cow (Bos taurus) (coverage 7×,Btau_4.6.1) [...] taking all the known α-keratin gene sequences of human as queries using BLASTN and TBLASTN algorithm. [...] [Using the putative α-keratin cow genes as query,] the orthologous α-keratin genes were also scanned from the genome of [marine mammals'] terrestrial relatives, such as [...] alpaca (Vicugna pacos, coverage 22×, Vicugna_pacos-2.0.1, NCBI)." | 10.1186/s12983-017-0225-x |
Curator Observations
The authors named the keratins according to the human nomenclature. Only Artiodactyla species (cetaceans excluded), where the gene was found to be lost (Fig1).