Ψ AADACL3 - Manis pentadactyla
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_IFC6ZO | Manis pentadactyla | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_036925107.2 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Timing of Loss | "Sequence analysis allowed the identification of a conserved single-nucleotide deletion in the third exon of Aadacl3, found in M. javanica, M. pentadactyla, and P. tricuspis, leading to the emergence of a premature stop codon." | 10.1007/s00239-023-10118-z |
| Phenotypic | "Ancestral (i.e., Awat1, Awat2, Aadacl3) and independent (i.e., Dgat2l6) pseudogenization events in genes associated with epidermal lipids and sebum production strongly suggest a progressive impairment of the sebum-producing molecular machinery in pangolin lineages" | 10.1007/s00239-023-10118-z |