Ψ PKD2L1 - Kogia sima

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_HRAN19 Kogia sima LOF (frameshift, premature stop, ss) Full Yes PCR & Sanger Sequencing Multiple

Statements

Type Excerpt DOI
Functional "Here we chose PKD2L1 to investigate whether cetaceans retained the sour taste modality, because mice lacking the Pkd2l1 gene have reduced sour taste ability and some people who are sour-ageusic also showed loss of the Pkd2l1 gene [38,39]." 10.1186/s12862-014-0218-8
Mutation Description "Based on sequence alignments against cow (Bos taurus) homologues, we identified multiple ORF-disrupting indels and premature stop codons in Tas1r1, Tas1r2, Pkd2l1 and in ten Tas2rs scattered among cetacean branches." 10.1186/s12862-014-0218-8
Mutation Description "For PKD2L1, the sole candidate sour taste receptor, we found two premature stop codons shared by all toothed whales, excluding the Dwarf sperm whale (Kogia sima) and a premature TGA stop codon shared by all cetaceans except for the baiji (Additional file 3: Figure S1)." 10.1186/s12862-014-0218-8
Other "SEE "Additional file 3: Figures S1-S11. Indels and premature stop codons in Pkdl21, Tas1r1, Tas1r2, Tas2r1-3, Tas2r5, Tas2r16, Tas2r38-39, and Tas2r60." 10.1186/s12862-014-0218-8

Curator Observations

Isolated sequences have been deposited by authors in GenBank [GenBank: KJ524713-KJ524837].