Ψ IL20 - Lipotes vexillifer
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_HIDKWR | Lipotes vexillifer | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic | XM_007470723.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Cetacean species IL20 gene annotation revealed the presence of several ORF disrupting mutations, of note a single transversal mutation present in all analyzed species, namely the abolition of a canonical donor splice site in exon 1 (Fig. 2a)." | 10.1007/s00251-018-1071-5 |
| Timing of Loss | "The sharing of a single conserved mutation in the donor splice site (GT>CT) of exon 1, along with the high ω rate calculated for the ancestral branch of cetaceans, suggests that IL20 pseudogenization occurred in the ancestor of whales and dolphins approximately 34 MYA (Pyenson 2017)." | 10.1007/s00251-018-1071-5 |
Curator Observations
Given the conservation of the LoF mutation in all cetacea including Lipotes vexillifer, and although genomic information is avaliable for only one individual of Lipotes we can safely assume that the loss in this lineage Full in other words affects all individuals.