Ψ AANAT - Delphinapterus leucas
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_H68HBF | Delphinapterus leucas | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_030762155.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "In summary, we were able to deduce the presence of multiple and shared disruptive mutations (Figure 1 and Figure S2). These included a stop codon in exon 1 present in all analysed Cetacea with the exception of P. catodon (exon 1 was not found in the current assembly), an absent starting codon and frameshift deletions in exon 3 in Odontoceti (toothed whales), and a disruptive intron 2/exon 3 boundary mutation in Mysticeti (baleen whales)." | 10.3390/genes10020121 |
| Timing of Loss | "Taken together, our results strongly suggest that melatonin production and signalling is impairedin Cetacea (Figure 6). Despite the lower number of disrupting mutations found in Asmt, we still find indications of pseudogenisation in the analysed species with the exception of B. mysticetus, due to poor genome coverage. Furthermore, we were able to infer that ancestral inactivating mutations (shared between toothed and toothless whales), occurred in Mtnr1b and Aanat ORFs." | 10.3390/genes10020121 |
Curator Observations
Also reported in : M Huelsmann. 2019 [PMID:31579821].