Ψ PCSK9 - Cuon alpinus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_GVZJNV | Cuon alpinus | Exon(s) deletion | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "In Caniformia, traces of gradual gene degradation over evolutionary time could still be found when comparing the basal Canidae to more recent families (Fig. 4). Indeed, while Canidae typically lack only exons 3 and 5, two additional deletions caused the loss of exons 4, 7 to 9 and part of exon 10 after the UrsidaeCanidae split, as evidenced by the sequences of Ursidae, Pinnipedia and Ailuridae." | 10.1007/s10709-021-00113-x |
| Timing of Loss | "In Carnivora, none of the 63 species analysed had a functional gene, but there was a marked difference in the pattern of gene inactivation between the suborders Caniformia and Feliformia." | 10.1007/s10709-021-00113-x |
Curator Observations
Although all Carnivora analyzed presented a PSCK9 Pseudogene, no ancestral shared mutation was identified between Caniformia and Feliformia.