Ψ KRT77 - Hexaprotodon liberiensis

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_GVAOSZ Hexaprotodon liberiensis LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Functional "Suprabasal epidermis keratin" 10.1016/j.cub.2021.02.057
Mutation Description ""1-3S (exon 1) 925-6816I (exon 4) 7252-7254P (exon 7)" D = deletion, I = insertion, P = premature stop codon, S = start codon mutation, M = mutated stop codon." 10.1016/j.cub.2021.02.057
Timing of Loss "45.75 MA" 10.1016/j.cub.2021.02.057
Other ""Eight of nine genes (ALOX15, AWAT1, KPRP, KRT2, KRT26, KRT77, KRTAP7-1, and TCHHL1) exhibit shared inactivating mutations in both hippopotamid species"" 10.1016/j.cub.2021.02.057

Curator Observations

See Table 2 for details regarding timing of loss. See Supplementary Table 2 for details regarding inactivating mutations.