Ψ DGAT2L6 - Manis javanica
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_G9FB4E | Manis javanica | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_017670833.2 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Timing of Loss | "Still, mutations were found to be conserved within the Manis genus (i.e., premature stops codons, nucleotide insertions, and losses of splice sites in multiple different exons), notably a two-nucleotide insertion in the second exon, leading to a premature stop codon, which was further validated by SRA analysis" | 10.1007/s00239-023-10118-z |
| Phenotypic | "Ancestral (i.e., Awat1, Awat2, Aadacl3) and independent (i.e., Dgat2l6) pseudogenization events in genes associated with epidermal lipids and sebum production strongly suggest a progressive impairment of the sebum-producing molecular machinery in pangolin lineages." | 10.1007/s00239-023-10118-z |