Ψ DGAT2L6 - Delphinapterus leucas

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_FAA7FW Delphinapterus leucas LOF (frameshift, premature stop, ss) Full Yes Multiple individual SRA

Statements

Type Excerpt DOI
Mutation Description "We identified several ORF disrupting mutations in both Dgat2l6 and Mogat3 in all of the analyzed Cetacea. Regarding Dgat2l6, a single mutation, namely a one nucleotide deletion in exon 3, was found to be conserved across all tested species..." 10.1093/molbev/msz068
Timing of Loss "Interestingly, the mutational pattern deduced in Dgat2l6, Mogat3, Awat1, Elovl3, and Fabp9 allowed the identification of conserved founding mutations common to all analyzed Cetacea (fig. 4). The sharing of mutations constitutes a strong indication of common pseudogenization events prior to the diversification of modern Cetacea lineages." 10.1093/molbev/msz068
Phenotypic "In conclusion, our study supports convergent gene loss events in key molecular components responsible for skin sebum production in lineages reported to lack functioning SGs (Sebaceous Glands)." 10.1093/molbev/msz068