| Methodology & Validation |
"We also performed an analysis using the CESAR method (Sharma et al., 2017) to further confirm the lost of RNase9 genes in five Cetacean genomes (Balaenoptera acutorostrata, Monodon Monoceros, Balaenoptera musculus, Phocoena sinus, and Tursiops truncatus)." |
10.1007/s11427-022-2195-x |
| Timing of Loss |
"We report a “birth-and-death” evolutionary trajectory for Cetartiodactyla RNase9 genes, with “birth” (gene duplication) on the Ruminantia common ancestral lineage and “death” (gene loss) occurring on the Cetacea lineage, suggesting that RNase9 experienced different evolutionary patterns in these two groups." |
10.1007/s11427-022-2195-x |
| Phenotypic |
"Studies have shown that RNase9 gene is uniquely and highly expressed in the epididymis of diverse mammals, including humans (Cheng et al., 2009), rats (Zhu et al., 2007), and mice (Penttinen et al., 2003), and that sperm motility is significantly impaired in RNase9 knockout mice (Westmuckett et al., 2014)." |
10.1007/s11427-022-2195-x |
| Other |
"..the distance between the RNase10 and RNase12 genes in the 26 Cetacean species was found to range from 22 to 63 kb, which is considerably shorter than the range of 76 to 126 kb found in other species of Ruminantia." |
10.1007/s11427-022-2195-x |