Ψ KRT6B - Ursus maritimus

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_E8WS9Q Ursus maritimus Gene deletion Full No Genomic & Synteny maps

Statements

Type Excerpt DOI
Functional "Previous study has reported that deficient for K6B (epithelial keratins) may contributed to the absence of hair and nail in mice." 10.1186/s12983-017-0225-x
Methodology & Validation "We first identified α-keratin gene repertoires in the cow (Bos taurus) (coverage 7×,Btau_4.6.1) [...] taking all the known α-keratin gene sequences of human as queries using BLASTN and TBLASTN algorithm. [...] The putative α-keratin genes in the cow were then taken as queries to explore the α-keratin multigene family in the genome of 11 marine mammals, including [...] Polar bear (Ursus maritimus, coverage 101×, UrsMar_1.0, NCBI)." 10.1186/s12983-017-0225-x
Phenotypic "Similar evolution pattern of α-keratin gene repertoire in the pinnipeds, polar bear and their terrestrial relatives is likely due to abundant hair to keep warm when they went ashore to mate, give birth, molt or escape from predators." 10.1186/s12983-017-0225-x
Other "By contrast, [α-keratin] gene repertoires in the pinnipeds (56) and polar bear (58) were similar to that of panda (58)." 10.1186/s12983-017-0225-x

Curator Observations

The authors named the keratins according to the human nomenclature. Gene not found in genomic maps-gene deletion (Fig1).