Ψ FLG - Trichechus manatus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_DTRKDR | Trichechus manatus | LOF (frameshift, premature stop, ss) | Undetermined | No | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "However, due to premature stop codons the proteins encoded by FLG, FLG2 and TCHHL1 are more than 50% shorter in sirenians than in elephants and humans (Fig. 5A, Supplementary Fig. S7)." | 10.1038/s41598-024-60099-2 |
| Other | "Interestingly, the manatee has a potentially functional FLG including the characteristic C-terminal sequence motif of SFTPs (Fig. 5B), whereas FLG of the dugong is truncated and lacks this motif." | 10.1038/s41598-024-60099-2 |
Curator Observations
Authors indicate that the protein has suffered a large truncation, due to a premature stop codon in the gene, but do not discard a functionality.