| Functional |
"In contrast, PCSK9 has clearly become non-functional in two Afrotheria species (the lesser hedgehog tenrec, Echinops telfairi and Talazac’s shrew tenrec, Microgale talazaci), as both carry multiple protein-inactivating defects strongly supported by the raw sequence data, including stop codons and frameshift insertions and deletions." |
10.1007/s10709-021-00113-x |
| Timing of Loss |
"Interestingly, both species belong to the family Tenrecidae, raising the possibility that PCSK9 pseudogenization is ancestral in tenrecs. However, there is no clear example of a shared inactivating alteration (the closest being a 1-bp deletion in one of the species overlapping with a 2-bp deletion in the other), so it is also formally possible that PCSK9 was independently lost in the two species." |
10.1007/s10709-021-00113-x |