Ψ PCSK9 - Enhydra lutris

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_D16MZM Enhydra lutris Exon(s) deletion Full Yes Genomic

Statements

Type Excerpt DOI
Mutation Description "In Caniformia, traces of gradual gene degradation over evolutionary time could still be found when comparing the basal Canidae to more recent families (Fig. 4). Indeed, while Canidae typically lack only exons 3 and 5, two additional deletions caused the loss of exons 4, 7 to 9 and part of exon 10 after the UrsidaeCanidae split, as evidenced by the sequences of Ursidae, Pinnipedia and Ailuridae." 10.1007/s10709-021-00113-x
Mutation Description "Finally, an additional two internal deletions led to the losses of exon 2 and the coding region of exon 12 seen in Mustelidae, while in the single species of Mephitidae available, a large deletion has left only exons 1, 2 and part of exon 12’s non-coding region. The breakpoints involved in this deletion, as well as those for the two Mustelidae-specific deletions and the earlier deletion from intron 6 to exon 10, are still identifiable through sequence comparisons among the relevant species." 10.1007/s10709-021-00113-x
Timing of Loss "In Carnivora, none of the 63 species analysed had a functional gene, but there was a marked difference in the pattern of gene inactivation between the suborders Caniformia and Feliformia." 10.1007/s10709-021-00113-x

Curator Observations

Applicable to Enhydra lutris kenyoni, as mentioned in the paper. Although all Carnivora analyzed presented a PCSK9 Pseudogene, no ancestral shared mutation was identified between Caniformia and Feliformia.