Ψ MC5R - Ceratotherium simum simum

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_CMH9XT Ceratotherium simum simum LOF (frameshift, premature stop, ss) Full No Genomic XM_014780327.1

Statements

Type Excerpt DOI
Mutation Description "In addition to taxa with deleted or mostly deleted copies of MC5R, we also discovered inactivating mutations in Loxodonta africana, Mammuthus primigenius (woolly mammoth), Ceratotherium simum (white rhinoceros), Galeopterus variegatus (Sunda colugo), Nomascus leucogenys (northern white-cheeked gibbon), and Pongo abelii (Sumatran orangutan) (Fig. 4)." 10.1016/j.ympev.2017.12.010
Mutation Description "The rhinocerotid C. simum has a premature stop codon at positions 73-75." 10.1016/j.ympev.2017.12.010
Phenotypic "Here, we show that MC5R has either been deleted from the genome or inactivated in multiple mammalian lineages that have lost their sebaceous glands or have degenerative sebaceous glands including fully aquatic cetaceans and West Indian manatee, pangolins, African elephant, and white rhinoceros." 10.1016/j.ympev.2017.12.010