Ψ F12 - Globicephala macrorhynchus
Reference Gene:
Job_ID:
Curator:
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Hageman factor (factor XII) is an initiation factor of plasma protease cascades, such as the intrinsic blood coagulation pathway and the plasma kinin system." | 10.1016/s0049-3848(97)00307-1 |
| Mutation Description | "Although all of the exon-intron assemblies predicted were identical to those of the human Hageman factor gene, there were two nonsense mutations making stop codons and a single nucleotide insertion causing a reading frame shift." | 10.1016/s0049-3848(97)00307-1 |
| Methodology & Validation | "We amplified two successive segments of the whale Hageman factor gene by polymerase chain reaction (PCR), and sequenced the PCR products with a combined total of 1367 base pairs. " | 10.1016/s0049-3848(97)00307-1 |
| Phenotypic | "...lack of these initiation factors of the intrinsic blood coagulation pathway must be advantageous to the marine mammals in prevention of disseminated intravascular coagulation syndrome which might occur in the semi-static state of blood circulation in the skin and the lungs under high hydrostatic pressure." | 10.1016/s0049-3848(97)00307-1 |
Curator Observations
Hageman Factor (Factor XII) is an alternative name for the F12 coagulation factor. Authors analyzes two individuals of this species.