Ψ UCP1 - Loxodonta africana
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_BSG9F1 | Loxodonta africana | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic | XM_064286259.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Adaptive nonshivering thermogenesis (NST) of placental mammals is predominantly mediated by uncoupling protein 1 (UCP1), which resides at high levels in the mitochondrial inner membrane of brown adipose tissue (BAT) (1)." | 10.1126/sciadv.1602878 |
| Timing of Loss | "For example, theearliest proboscideans [59 to 60 million–year–old (Ma) Eritherium(41)] and hyraxes [~55-Ma Seggeurius (42)] were small (~3 to 5 kg)but gave rise to much larger species (for example, 3600-kg Barytheriumand 800- to 1400-kg Titanohyrax ulitimus), coincident with our esti-mates of ucp1 inactivation. Although large-bodied (~625- to 800-kg)hyracoids such as “Titanohyrax” mongereaui are also known from ear-lier deposits, the presence of only a single, “primitive” Seggeurius-sizedspecies (Dimaitherium patnaiki) from the early Priabonian (~37 Ma)suggests that gigantism evolved independently in Middle and Late Eo-cene hyracoids (43). " | 10.1126/sciadv.1602878 |
Curator Observations
A conserved deletion of 1bp was observed in all elephant species
Related Glosses
| GL_ID | Symbol | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|---|
| GL_LYVTU7 | UCP1 | Loxodonta africana | Proboscidea | LOF (frameshift, premature stop, ss) | Full | No | 10.1073/pnas.2106080118 |