Ψ TAS1R2 - Tursiops truncatus

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_BI3MW1 Tursiops truncatus LOF (frameshift, premature stop, ss) Full Yes PCR & Sanger Sequencing Single XM_019918966.2

Statements

Type Excerpt DOI
Mutation Description "Based on sequence alignments against cow (Bos taurus) homologues, we identified multiple ORF-disrupting indels and premature stop codons in Tas1r1, Tas1r2, Pkd2l1 and in ten Tas2rs scattered among cetacean branches." 10.1186/s12862-014-0218-8
Timing of Loss "For Tas1r2, a 5 bp deletion was found on the stem Odontoceti (Additional file 3: Figure S3), suggesting that the pseudogenization event had happened in the common ancestor of the Odontoceti." 10.1186/s12862-014-0218-8
Phenotypic "Considering that both Tas1r1 and Tas1r2 had been identified as pseudogenes, we speculated that the umami and sweet tastes had been lost in the cetaceans." 10.1186/s12862-014-0218-8
Other "SEE "Additional file 3: Figures S1-S11. Indels and premature stop codons in Pkdl21, Tas1r1, Tas1r2, Tas2r1-3, Tas2r5, Tas2r16, Tas2r38-39, and Tas2r60." 10.1186/s12862-014-0218-8

Curator Observations

Isolated sequences have been deposited by authors in GenBank [GenBank: KJ524713-KJ524837]. Gene loss shared in Odontoceti species.

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_9QGLWY TAS1R2 Tursiops truncatus Artiodactyla Exon(s) deletion Full No 10.1186/s40851-014-0002-z
GL_OUOX5B TAS1R2 Tursiops truncatus Artiodactyla LOF (frameshift, premature stop, ss) Full No 10.1073/pnas.1118360109
GL_UXNI64 TAS1R2 Tursiops truncatus Artiodactyla Other Full No 10.1038/s41467-018-03667-1