Gene Loss

GlossID	Species	Gene Loss Mechanism	Loss Type	Lineage Specific	Evidence	Accession Nr.
GL_AO1S9Q	Lagenorhynchus obliquidens	LOF (frameshift, premature stop, ss)	Full	Yes	Single individual SRA	XM_027081366.1

Type	Excerpt	DOI
Mutation Description	"In summary, we were able to deduce the presence of multiple and shared disruptive mutations (Figure 1 and Figure S2). These included a stop codon in exon 1 present in all analysed Cetacea with the exception of P. catodon (exon 1 was not found in the current assembly), an absent starting codon and frameshift deletions in exon 3 in Odontoceti (toothed whales), and a disruptive intron 2/exon 3 boundary mutation in Mysticeti (baleen whales)."	10.3390/genes10020121
Timing of Loss	"Taken together, our results strongly suggest that melatonin production and signalling is impaired in Cetacea (Figure 6). Despite the lower number of disrupting mutations found in Asmt, we still fin indications of pseudogenisation in the analysed species with the exception of B. mysticetus, due to poor genome coverage. Furthermore, we were able to infer that ancestral inactivating mutations (shared between toothed and toothless whales), occurred in Mtnr1b and Aanat ORFs."	10.3390/genes10020121