Ψ MOGAT3 - Delphinapterus leucas

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_ACJIJV Delphinapterus leucas LOF (frameshift, premature stop, ss) Full Yes Multiple individual SRA XM_030763570.1

Statements

Type Excerpt DOI
Functional "Thus, two scenarios could be put forward regarding the inactivation of Mogat3. First, it could reflect convergent skin-specific molecular changes, more specifically degeneration of SGs or changes in sebum lipid composition(Nikkari 1974)." 10.1093/molbev/msz068
Functional "Alternatively, Mogat3 loss could be related to dietary adaptations, especially to herbivory, as in the case of T. m. latirostris, C. s. simum and L. africana." 10.1093/molbev/msz068
Mutation Description "We identified several ORF disrupting mutations in both Dgat2l6 and Mogat3 in all of the analyzed Cetacea. Regarding Dgat2l6, a single mutation, namely a one nucleotide deletion in exon 3, was found to be conserved across all tested species, whereas in Mogat3 several conserved mutations were identified, such as a five nucleotide insertion in exon 2, a loss of canonical 30splice site in exon 3 (GT>GC) and the presence of a stop codon in exon 6 (fig. 2A)." 10.1093/molbev/msz068

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_ZOMZEH MOGAT3 Delphinapterus leucas Artiodactyla Other Full Cetacea 10.1016/j.cub.2021.02.057