Ψ OXCT2 - Orcinus orca
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_9ORFA1 | Orcinus orca | LOF (frameshift, premature stop, ss) | Full | Yes | Multiple individual SRA | XM_012531769.3 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "Together, most of these metabolic steps are controlled by sperm-restricted gene orthologs, including (...) the 3-Oxoacid CoA-transferase 2 (Oxct2), which converts ketone-body-derived acetoacetate into acetoacetyl-CoA in sperm cells (Figure 2).24 We examined each gene ortholog sequence in various mammal species and found ORF-disrupting mutations or exon-loss events in most cetacean species (Figure 2; figshare link in Key resources table)." | 10.1016/j.cub.2021.05.062 |
Curator Observations
This gene is duplicated in Cetacea. The second copy in O. orca also presents LOF mutations.