Ψ NLRP1 - Physeter catodon
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_7PG4VW | Physeter catodon | Other | Full | No | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Methodology & Validation | "The genome sequences (…) were investigated for the presence and sequence integrity of genes related to pyroptosis and IL-1 signaling." | 10.1038/s41598-017-17782-4 |
| Timing of Loss | "Our comparative genomics data indicate that NLRP10 as well as NLRP1 have been lost in a common ancestor of cetaceans and cattle, indicating that its function was dispensable or even disadvantageous. As this ancestor had a terrestrial lifestyle, loss of NLRP10 was likely not associated with a change in the epidermal differentiation program but perhaps with the regulation of immune responses to pathogens." | 10.1038/s41598-017-17782-4 |
Curator Observations
Figure 3. Authors do not provide details regarding Gene loss mechanism.