Ψ UCP1 - Equus caballus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_7KMQ6L | Equus caballus | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic | XM_001915531.2 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Adaptive nonshivering thermogenesis (NST) of placental mammals is predominantly mediated by uncoupling protein 1 (UCP1), which resides at high levels in the mitochondrial inner membrane of brown adipose tissue (BAT) (1)." | 10.1126/sciadv.1602878 |
| Timing of Loss | "Potential thermogenic limitations arising from UCP1 loss [as suggested for suids (25)] were clearly not an impediment to the ability of equines to exploit cold environments given “that Alaskan horses prospered during the LGM [last glacial maximum; ~18,000 years ago], and appear to have been particularly well adapted to the more intense versions of the cold/arid Mammoth Steppe (44)." | 10.1126/sciadv.1602878 |
Curator Observations
A conserved premature Stop codon in exon 2 was observed in all Equus species analyzed (see fig. 1).
Related Glosses
| GL_ID | Symbol | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|---|
| GL_W1VAJS | UCP1 | Equus caballus | Perissodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1073/pnas.2106080118 |