Ψ TAS2R1 - Neophocaena phocaenoides

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_7IQBQY Neophocaena phocaenoides LOF (frameshift, premature stop, ss) Full Yes PCR & Sanger Sequencing Single

Statements

Type Excerpt DOI
Functional "Li et al. (2014) [47] investigated Tas2rs gene repertoires in vertebrates, and they demonstrated that dietary toxins are a major selective force shaping the diversity of the Tas2r repertoire." 10.1186/s12862-014-0218-8
Mutation Description "Based on sequence alignments against cow (Bos taurus) homologues, we identified multiple ORF-disrupting indels and premature stop codons in Tas1r1, Tas1r2, Pkd2l1 and in ten Tas2rs scattered among cetacean branches." 10.1186/s12862-014-0218-8
Mutation Description "Compared with corresponding functional sequences of Tas2r1, we found a 1 bp deletion in three species of Delphinidae, a premature stop codon (TGA) in all cetaceans except for the Dwarf sperm whale, and another premature stop codon (TGA) in four toothed whales (Additional file 3: Figure S4)." 10.1186/s12862-014-0218-8
Other "SEE "Additional file 3: Figures S1-S11. Indels and premature stop codons in Pkdl21, Tas1r1, Tas1r2, Tas2r1-3, Tas2r5, Tas2r16, Tas2r38-39, and Tas2r60." 10.1186/s12862-014-0218-8

Curator Observations

Isolated sequences have been deposited by authors in GenBank [GenBank: KJ524713-KJ524837]. A highly conserved Stop codon suggests that the loss of this gene occurred in the cetacean ancestral.