Ψ PCSK9 - Tragulus kanchil

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_6CDDH1 Tragulus kanchil Exon(s) deletion Full Yes Genomic

Statements

Type Excerpt DOI
Mutation Description "(...) a large deletion extending from the BSND-PCSK9 intergenic region to exon 7." 10.1007/s10709-021-00113-x
Mutation Description "The first of these structural alterations was also recognizable in the lesser mouse-deer (Tragulus kanchil), in which a different deletion, extending from intron 8 to the PCSK9-USP24 intragenic region, was identified in the genomic sequence." 10.1007/s10709-021-00113-x
Timing of Loss "The loss of PCSK9 in Cetartiodactyla can thus be inferred to have taken place in the time interval from the Whippomorpha- Ruminantia split (ca. 70 My bp) to the divergence of Ruminantia (ca. 52 My bp)." 10.1007/s10709-021-00113-x

Curator Observations

Authors identified a shared large deletion in all Ruminantia analyzed.