Ψ RIPK3 - Globicephala melas
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_4PUNMY | Globicephala melas | LOF (frameshift, premature stop, ss) | Full | No | Genomic | XM_060293483.1 |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Mutation Description | "In Cetacean species, the disruption of RIPK3 occurred at different positions depending on the studied species: a frameshift mutation was identified in exon 6 of two Delphinidae species, as well as in exon 8 of two Phocoenidae species, one Monodontidae species and one Balaenopteridae species. There was also evidence of two species (one species from Monodontidae and another from Lipotidae families) with RIPK3 pseudogenes based on the presence of a stop codon located in exon 2 (Supplementary File 6)." | 10.3389/fimmu.2021.747737 |
Curator Observations
Although no single conserved mutation can be identified mapping the gene loss event to the lineage ancestor, all species analyzed in cetacea presented inactivating mutations in this gene.