Ψ UCP1 - Sus scrofa

Reference Gene:
Job_ID:
Curator:
GlossID Species Gene Loss Mechanism Loss Type Lineage Specific Evidence Accession Nr.
GL_21VNSY Sus scrofa LOF (frameshift, premature stop, ss) Full Yes Genomic

Statements

Type Excerpt DOI
Functional "Adaptive nonshivering thermogenesis (NST) of placental mammals is predominantly mediated by uncoupling protein 1 (UCP1), which resides at high levels in the mitochondrial inner membrane of brown adipose tissue (BAT) (1)." 10.1126/sciadv.1602878
Timing of Loss "Loss of ucp1 in pigs has been previously dated to ~20 Ma (25). However, the absence of BAT in newborn peccaries (17) suggests that its inactivation may have predated the divergence of Suoidea in the Late Eocene to Early Oligocene (45, 46). Owing to a fragmentary fossil record, potential selection pressures favoring ucp1 inactivation in early suids remain unclear, although it is notable that—like whales and adult pinnipeds—cold-stressed domestic swine shunt blood away from the entire body surface, thereby forming a steep thermal gradient to minimize heat loss (47). Nonetheless, loss of BAT has not prevented exploitation of cold north temperature niches by some members of this clade " 10.1126/sciadv.1602878

Curator Observations

Several conserved mutations were observed in all Sus species analyzed for exemple: loss of start codon ATG>CTG, 16bp deletion in exon 2 and deletion of exon 3,4 and 5(see fig. 1).

Related Glosses

GL_ID Symbol Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_XE7MS2 UCP1 Sus scrofa Artiodactyla Gene deletion Full No 10.1073/pnas.2106080118