Ψ UCP1 - Bradypus variegatus
Reference Gene:
Job_ID:
Curator:
| GlossID | Species | Gene Loss Mechanism | Loss Type | Lineage Specific | Evidence | Accession Nr. |
|---|---|---|---|---|---|---|
| GL_0VIIUZ | Bradypus variegatus | LOF (frameshift, premature stop, ss) | Full | Yes | Genomic |
Statements
| Type | Excerpt | DOI |
|---|---|---|
| Functional | "Adaptive nonshivering thermogenesis (NST) of placental mammals is predominantly mediated by uncoupling protein 1 (UCP1), which resides at high levels in the mitochondrial inner membrane of brown adipose tissue (BAT) (1)." | 10.1126/sciadv.1602878 |
| Timing of Loss | "The earliest disruptions of ucp1 function (likely Cretaceous; Fig. 3and table S3) occur in the ancestors of xenarthrans and pangolins,two groups that exhibit marked convergence in many ecological,morphological, and physiological traits and which are generallycharacterized by mediocre temperature-regulating mechanismsand low, labile body temperatures (29–32)" | 10.1126/sciadv.1602878 |
Curator Observations
Loss of exons 1,2,3,4 and 5 in all Xenarthra