Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
Uox urate oxidase		Mus musculus	8	protein-coding		1.7.3.3

Summary

Enables urate oxidase activity. Involved in allantoin metabolic process; purine-containing compound catabolic process; and urate catabolic process. Located in mitochondrion. Is active in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Used to study hyperuricemia; kidney disease; and nephrogenic diabetes insipidus. Orthologous to human UOX (urate oxidase (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0016491	enables oxidoreductase activity	IEA

Component (6)

Go ID	Value	Evidence
0005829	located_in cytosol	TAS
0005739	located_in mitochondrion	HDA
0005777	is_active_in peroxisome	IBA
0005777	is_active_in peroxisome	IDA
0005777	located_in peroxisome	ISO
0005777	located_in peroxisome	TAS

Process (20)

Go ID	Value	Evidence
0006196	involved_in AMP catabolic process	IDA
0046038	involved_in GMP catabolic process	IDA
0006204	involved_in IMP catabolic process	IDA
0006154	involved_in adenosine catabolic process	IDA
0000255	involved_in allantoin metabolic process	IDA
0043605	involved_in amide catabolic process	IDA
0046059	involved_in dAMP catabolic process	IDA
0046055	involved_in dGMP catabolic process	IDA
0006157	involved_in deoxyadenosine catabolic process	IDA
0006161	involved_in deoxyguanosine catabolic process	IDA
0006149	involved_in deoxyinosine catabolic process	IDA
0006147	involved_in guanine catabolic process	IDA
0009114	involved_in hypoxanthine catabolic process	IDA
0006148	involved_in inosine catabolic process	IDA
0006145	involved_in purine nucleobase catabolic process	IBA
0006144	acts_upstream_of_or_within purine nucleobase metabolic process	TAS
0019628	involved_in urate catabolic process	IBA
0019628	involved_in urate catabolic process	IDA
0019628	involved_in urate catabolic process	ISO
0009115	involved_in xanthine catabolic process	IDA

Gene Loss events - Uox (3 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_6VTOGD	Loxodonta africana	Proboscidea	LOF (frameshift, premature stop, ss)	Full	Elephantidae	10.1093/nargab/lqz012
GL_RVJCSB	Trichechus manatus latirostris	Sirenia	LOF (frameshift, premature stop, ss)	Full		10.1093/nargab/lqz012
GL_XGGVWA	Elephas maximus indicus	Proboscidea	LOF (frameshift, premature stop, ss)	Full	Elephantidae	10.1093/nargab/lqz012