Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
PDHA2 pyruvate dehydrogenase E1 subunit alpha 2	PDHAL , SPGF70	Homo sapiens	1	protein-coding		1.2.4.1	179061

Summary

Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in pyruvate metabolic process. Located in mitochondrion and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005515	enables protein binding	IPI

Component (5)

Go ID	Value	Evidence
0005759	located_in mitochondrial matrix	TAS
0005739	located_in mitochondrion	IDA
0005739	located_in mitochondrion	NAS
0005730	located_in nucleolus	IDA
0005634	located_in nucleus	HDA

Process (5)

Go ID	Value	Evidence
0006086	involved_in acetyl-CoA biosynthetic process from pyruvate	IBA
0006086	involved_in acetyl-CoA biosynthetic process from pyruvate	ISS
0006006	involved_in glucose metabolic process	IEA
0006090	involved_in pyruvate metabolic process	IDA
0006099	involved_in tricarboxylic acid cycle	IEA

Gene Loss events - PDHA2 (27 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_RCWQHD	Eubalaena glacialis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_T8UPNJ	Balaenoptera acutorostrata	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_UL2CSA	Balaenoptera bonaerensis	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_W8CEQX	Delphinapterus leucas	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_WQG3VC	Kogia breviceps	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_ZDXXLW	Tursiops truncatus	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062
GL_ZGS4DC	Eubalaena japonica	Artiodactyla	LOF (frameshift, premature stop, ss)	Full	Cetacea	10.1016/j.cub.2021.05.062

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