Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| CRNN cornulin | DRC1 , PDRC1 , SEP53 , C1orf10 | Homo sapiens | 3 | protein-coding | S100A5 , S100A2 , S100A3 , S100A4 , S100A6 , S100Z | 611312 |
Summary
This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009]
Gene Loss events - CRNN (4 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_4T5TVB | Phocoena sinus | Artiodactyla | Other | Full | No | 10.1038/s41598-021-91863-3 |
| GL_FHXKQ0 | Balaenoptera musculus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41598-021-91863-3 |
| GL_O2S0JB | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41598-021-91863-3 |
| GL_UQYL2V | Tursiops truncatus | Artiodactyla | Other | Full | No | 10.1038/s41598-021-91863-3 |