Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| AMTN amelotin | AI3B , UNQ689 | Homo sapiens | 9 | protein-coding | 610912 |
Summary
The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]
Gene Loss events - AMTN (7 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_7DVQ0Z | Balaenoptera musculus | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_BMYTWG | Neophocaena asiaeorientalis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_JNJZVB | Kogia breviceps | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_K7EJMK | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_O8UXSL | Balaenoptera bonaerensis | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_RXHPWW | Phocoena phocoena | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |
| GL_SQKC7Y | Delphinapterus leucas | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1016/j.ympev.2022.107463 |