Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
MC5R melanocortin 5 receptor	MC2	Homo sapiens	2	protein-coding	GPR119 , S1PR2 , LPAR1 , MC4R , GPR12 , S1PR5 , GPR3 , GPR6 , MC3R , MC1R , MC2R , S1PR4 , LPAR3 , LPAR2 , S1PR3 , S1PR1 , CNR2 , CNR1		600042

Summary

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

GeneOntology

Function (1)

Go ID	Value	Evidence
0042562	enables hormone binding	IEA

Component (4)

Go ID	Value	Evidence
0005737	is_active_in cytoplasm	IBA
0005886	is_active_in plasma membrane	IBA
0005886	located_in plasma membrane	IDA
0005886	located_in plasma membrane	TAS

Process (4)

Go ID	Value	Evidence
0007187	involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS
0007189	involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
0007189	involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA
0019222	involved_in regulation of metabolic process	IBA

Gene Loss events - MC5R (17 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_MKUEYS	Balaena mysticetus	Artiodactyla	Gene deletion	Full	Cetacea	10.1016/j.ympev.2017.12.010
GL_Q5CIYG	Balaenoptera bonaerensis	Artiodactyla	Gene deletion	Full	Cetacea	10.1016/j.ympev.2017.12.010
GL_QV5MF2	Loxodonta africana	Proboscidea	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.12.010
GL_UEMKCP	Lipotes vexillifer	Artiodactyla	Gene deletion	Full	Cetacea	10.1016/j.ympev.2017.12.010
GL_X1MD1D	Pongo abelii	Primates	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.12.010
GL_XR46X9	Mammuthus primigenius	Proboscidea	LOF (frameshift, premature stop, ss)	Full	No	10.1016/j.ympev.2017.12.010
GL_YGX7DW	Tursiops truncatus	Artiodactyla	Gene deletion	Full	Cetacea	10.1016/j.ympev.2017.12.010