Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| IL37 interleukin 37 | FIL1 , FIL1Z , IL-1H , IL-23 , IL-37 , IL1F7 , IL1H4 , IL-1F7 , IL-1H4 , IL1RP1 , IL-1RP1 , FIL1(ZETA) | Homo sapiens | 7 | protein-coding | IL1F10 , IL1RN , IL36A , IL36B , IL36G , IL36RN , IL18 , IL1A , IL1B | 605510 |
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Loss events - IL37 (5 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_B2PEBE | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41598-017-17782-4 |
| GL_MFWUUB | Orcinus orca | Artiodactyla | Gene deletion | Full | No | 10.1038/s41598-017-17782-4 |
| GL_PQKWSD | Lipotes vexillifer | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41598-017-17782-4 |
| GL_TAVQGI | Tursiops truncatus | Artiodactyla | Gene deletion | Full | No | 10.1038/s41598-017-17782-4 |
| GL_XASDZ8 | Physeter catodon | Artiodactyla | Gene deletion | Full | No | 10.1038/s41598-017-17782-4 |