Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| IL36A interleukin 36 alpha | FIL1 , FIL1E , IL1F6 , IL-1F6 , IL1(EPSILON) , FIL1(EPSILON) | Homo sapiens | 6 | protein-coding | IL1F10 , IL1RN , IL36B , IL37 , IL36G , IL36RN , IL18 , IL1A , IL1B | 605509 |
Summary
The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
Gene Loss events - IL36A (5 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_GUDGYF | Orcinus orca | Artiodactyla | Gene deletion | Full | Cetacea | 10.1038/s41598-017-17782-4 |
| GL_HVX4BI | Lipotes vexillifer | Artiodactyla | Gene deletion | Full | Cetacea | 10.1038/s41598-017-17782-4 |
| GL_NYHDJN | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1038/s41598-017-17782-4 |
| GL_QJ2SQU | Tursiops truncatus | Artiodactyla | Gene deletion | Full | Cetacea | 10.1038/s41598-017-17782-4 |
| GL_YJC2WB | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | Cetacea | 10.1038/s41598-017-17782-4 |