Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
MX2 MX dynamin like GTPase 2 MXB Homo sapiens 18 protein-coding OPA1 , DNM1L , MX1 , DNM2 , DNM3 , DNM1 147890

Summary

The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]

Gene Loss events - MX2 (3 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_4JGE8B Physeter catodon Artiodactyla Other Full No 10.1038/s41467-018-03667-1
GL_CMQXUK Orcinus orca Artiodactyla Other Full No 10.1038/s41467-018-03667-1
GL_VZX6BK Tursiops truncatus Artiodactyla Other Full No 10.1038/s41467-018-03667-1