Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
BOK BCL2 family apoptosis regulator BOK BOKL , BCL2L9 Homo sapiens 7 protein-coding BCL2L2 , BCL2L1 , BCL2 , BCL2L10 , BAK1 , MCL1 , BAX , BCL2A1 605404

Summary

The protein encoded by this gene belongs to the BCL2 family, members of which form homo- or heterodimers, and act as anti- or proapoptotic regulators that are involved in a wide variety of cellular processes. Studies in rat show that this protein has restricted expression in reproductive tissues, interacts strongly with some antiapoptotic BCL2 proteins, not at all with proapoptotic BCL2 proteins, and induces apoptosis in transfected cells. Thus, this protein represents a proapoptotic member of the BCL2 family. [provided by RefSeq, Sep 2011]

Gene Loss events - BOK (1 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_6DCZ1M Canis lupus familiaris Carnivora Other Full No 10.1038/s41467-018-03667-1