Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| BCO1 beta-carotene oxygenase 1 | BCO , BCDO , BCMO , BCDO1 , BCMO1 | Homo sapiens | 11 | protein-coding | RPE65 , BCO2 | 1.13.11.63 | 605748 |
Summary
Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
Gene Loss events - BCO1 (1 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_KPTG9P | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1038/s41467-018-03667-1 |