Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
UBE2S ubiquitin conjugating enzyme E2 S	EPF5 , E2EPF , E2-EPF	Homo sapiens	5	protein-coding	UBE2F , UBE2M , UBE2J1 , UBE2H , UBE2K , UBE2J2 , UBE2V2 , UBE2V1 , UBE2T , UBE2C , UBE2W , UBE2L6 , UBE2L5 , UBE2L3 , UBE2D3 , UBE2D2 , UBE2D1 , UBE2D4 , UBE2E2 , UBE2E3 , UBE2E1 , UBE2Q1 , UBE2Q2 , UBE2QL1 , AKTIP , UBE2NL , UBE2N	2.3.2.23	610309

Summary

This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (4)

Go ID	Value	Evidence
0005680	part_of anaphase-promoting complex	IDA
0005829	located_in cytosol	TAS
0005654	located_in nucleoplasm	TAS
0005634	is_active_in nucleus	IBA

Process (16)

Go ID	Value	Evidence
0031145	involved_in anaphase-promoting complex-dependent catabolic process	IDA
0051301	involved_in cell division	IEA
0010458	involved_in exit from mitosis	IDA
0010458	involved_in exit from mitosis	IMP
0010994	involved_in free ubiquitin chain polymerization	IDA
1904668	involved_in positive regulation of ubiquitin protein ligase activity	IDA
0043161	involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA
0070979	acts_upstream_of_or_within protein K11-linked ubiquitination	IDA
0070979	involved_in protein K11-linked ubiquitination	IDA
0044314	involved_in protein K27-linked ubiquitination	IDA
0035519	involved_in protein K29-linked ubiquitination	IDA
0085020	involved_in protein K6-linked ubiquitination	IDA
0070534	involved_in protein K63-linked ubiquitination	IDA
0036211	involved_in protein modification process	TAS
0000209	involved_in protein polyubiquitination	IBA
0006511	involved_in ubiquitin-dependent protein catabolic process	IBA

Gene Loss events - UBE2S (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_8ZCWSP	Physeter catodon	Artiodactyla	Other	Full	No	10.1007/s12041-021-01333-y