Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| MIP major intrinsic protein of lens fiber | AQP0 , LIM1 , MP26 , MIP26 , CTRCT15 | Homo sapiens | 8 | protein-coding | AQP1 , AQP2 , AQP6 , AQP5 , AQP4 , TNPO2 , MIPEP , MIPEP , AQP1 , AQP2 , AQP6 , AQP5 , MIP , TNPO2 , MIPEP , MIPEP , AQP1 , AQP2 , AQP6 , AQP5 , MIP , TNPO2 , NLN , THOP1 | 1.11.1.6 | 154050 |
Summary
Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]
GeneOntology
Gene Loss events - MIP (2 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_5DQY2W | Condylura cristata | Eulipotyphla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_JDGJI7 | Chrysochloris asiatica | Afrosoricida | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |