Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| CRYGC crystallin gamma C | CCL , CRYG3 , CTRCT2 | Homo sapiens | 3 | protein-coding | CRYBG1 , CRYBA2 , CRYBG2 , CRYBB2 , CRYBA1 , CRYBA4 , CRYGN , CRYBG3 , CRYBB1 , CRYBB3 , CRYGS , CRYGA , CRYGD , CRYGB | 123680 |
Summary
This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]
GeneOntology
Gene Loss events - CRYGC (6 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_2JLYUQ | Chrysochloris asiatica | Afrosoricida | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_BNNGCE | Condylura cristata | Eulipotyphla | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_CPK8AL | Miniopterus natalensis | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_ILOSMU | Nannospalax galili | Rodentia | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_IUE1BX | Leptonychotes weddellii | Carnivora | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_ZFPZCR | Otolemur garnettii | Primates | Gene deletion | Full | No | 10.1093/icb/icy004 |