Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
CCDC66 coiled-coil domain containing 66		Homo sapiens	23	protein-coding			619287

Summary

Enables microtubule binding activity. Involved in cilium assembly; microtubule bundle formation; and regulation of protein localization to cilium. Located in several cellular components, including Flemming body; microtubule cytoskeleton; and photoreceptor inner segment. [provided by Alliance of Genome Resources, Apr 2022]

GeneOntology

Function (1)

Go ID	Value	Evidence
0008017	enables microtubule binding	IBA

Component (14)

Go ID	Value	Evidence
0090543	located_in Flemming body	IDA
0030054	located_in cell junction	IDA
0034451	located_in centriolar satellite	IDA
0005813	located_in centrosome	IDA
0036064	located_in ciliary basal body	IDA
0035869	NOT colocalizes_with ciliary transition zone	IDA
0005929	is_active_in cilium	IBA
0005929	located_in cilium	IDA
0005829	located_in cytosol	IDA
0005874	is_active_in microtubule	IBA
0005874	located_in microtubule	IDA
0001917	is_active_in photoreceptor inner segment	IBA
0001917	located_in photoreceptor inner segment	IDA
0001750	located_in photoreceptor outer segment	IEA

Process (6)

Go ID	Value	Evidence
0060271	involved_in cilium assembly	IBA
0060271	involved_in cilium assembly	IMP
0050908	involved_in detection of light stimulus involved in visual perception	IEA
0001578	involved_in microtubule bundle formation	IMP
1903564	involved_in regulation of protein localization to cilium	IMP
0001895	involved_in retina homeostasis	ISS

Gene Loss events - CCDC66 (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_1GIUCG	Erinaceus europaeus	Eulipotyphla	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004