Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| GUCA1B guanylate cyclase activator 1B | RP48 , GCAP2 , GUCA2 , GCAP 2 , GCAP-2 , GCAP-II | Homo sapiens | 4 | protein-coding | CLXN , KCNIP3 , KCNIP1 , KCNIP2 , KCNIP4 , VSNL1 , HPCAL4 , GUCA1A , NCALD , RCVRN , HPCA , GUCA1C , HPCAL1 , NCS1 | 602275 |
Summary
The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]
GeneOntology
Gene Loss events - GUCA1B (7 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_CB27S9 | Heterocephalus glaber | Rodentia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_HZO7FC | Echinops telfairi | Gene deletion | Full | No | 10.1093/icb/icy004 | |
| GL_I0N43S | Condylura cristata | Eulipotyphla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_MBQFEX | Chrysochloris asiatica | Afrosoricida | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_R4NXAO | Nannospalax galili | Rodentia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_XVYTMZ | Sorex araneus | Eulipotyphla | Gene deletion | Full | No | 10.1093/icb/icy004 |
| GL_YIU3IB | Miniopterus natalensis | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |