Reference Gene
| Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
|---|---|---|---|---|---|---|---|
| RABGGTB Rab geranylgeranyltransferase subunit beta | GGTB | Homo sapiens | 11 | protein-coding | FNTB , PGGT1B | 2.5.1.60 | 179080 |
Summary
This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]
GeneOntology
Gene Loss events - RABGGTB (6 results)
| GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
|---|---|---|---|---|---|---|
| GL_5EG2DA | Trichechus manatus | Sirenia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_8OSEN1 | Orycteropus afer | Tubulidentata | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_GHEOMY | Chrysochloris asiatica | Afrosoricida | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_N6IVOD | Physeter catodon | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_TBCLGP | Balaenoptera acutorostrata | Artiodactyla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
| GL_YSAUFN | Condylura cristata | Eulipotyphla | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |