Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
RRH retinal pigment epithelium-derived rhodopsin homolog		Homo sapiens	7	protein-coding	RGR , GPR88 , OPN4 , OPN5 , RHO , OPN1MW2 , OPN1MW3 , OPN1MW , OPN1LW , OPN1SW , OPN1SW , OPN3 , GPR52		605224

Summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes opsin 5 and retinal G protein coupled receptor. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0008020	enables G protein-coupled photoreceptor activity	IBA

Component (2)

Go ID	Value	Evidence
0001750	is_active_in photoreceptor outer segment	IBA
0005886	is_active_in plasma membrane	IBA

Process (5)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IBA
0071482	involved_in cellular response to light stimulus	IBA
0009584	involved_in detection of visible light	IEA
0007602	involved_in phototransduction	IBA
0007601	involved_in visual perception	IEA

Gene Loss events - RRH (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_XXA3SI	Nannospalax galili	Rodentia	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004