Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
SEMA5B semaphorin 5B	SemG , SEMAG	Homo sapiens	26	protein-coding	SEMA6C , SEMA6D , SEMA6B , SEMA6A , SEMA5A , SEMA7A , SEMA3A , SEMA3D , SEMA4C , SEMA3G , SEMA4A , SEMA4B , SEMA3C , SEMA3E , SEMA3B , SEMA3F , SEMA4F , SEMA4G , SEMA4D		609298

Summary

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneOntology

Function (1)

Go ID	Value	Evidence
0045499	enables chemorepellent activity	IBA

Component (1)

Go ID	Value	Evidence
0005886	is_active_in plasma membrane	IBA

Process (7)

Go ID	Value	Evidence
0048675	involved_in axon extension	IBA
0007411	involved_in axon guidance	IBA
0050908	involved_in detection of light stimulus involved in visual perception	IEA
0050919	involved_in negative chemotaxis	IEA
0001755	involved_in neural crest cell migration	IBA
0030335	involved_in positive regulation of cell migration	IBA
0071526	involved_in semaphorin-plexin signaling pathway	IBA

Gene Loss events - SEMA5B (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_YLFTAB	Canis lupus familiaris	Carnivora	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004