Reference Gene
Gene name | Alias | Species | Exons | Type | Paralogs | EC number | OMIM |
---|---|---|---|---|---|---|---|
PPEF2 protein phosphatase with EF-hand domain 2 | PPP7CB | Homo sapiens | 17 | protein-coding | PPEF1 , PPP5C | 3.1.3.16 | 602256 |
Summary
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008]
GeneOntology
Gene Loss events - PPEF2 (7 results)
GL_ID | Species | Order | Gene Loss Mechanism | Loss Type | Lineage Specific | Citation |
---|---|---|---|---|---|---|
GL_CTGEO8 | Fukomys damarensis | Rodentia | Gene deletion | Full | No | 10.1093/icb/icy004 |
GL_DMDDHR | Chrysochloris asiatica | Afrosoricida | Gene deletion | Full | No | 10.1093/icb/icy004 |
GL_NCERUV | Sorex araneus | Eulipotyphla | Gene deletion | Full | No | 10.1093/icb/icy004 |
GL_PX4WCW | Nannospalax galili | Rodentia | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
GL_XBPHAT | Miniopterus natalensis | Chiroptera | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |
GL_XDTRKK | Rhinolophus sinicus | Chiroptera | Gene deletion | Full | No | 10.1093/icb/icy004 |
GL_XM5DG9 | Manis javanica | Pholidota | LOF (frameshift, premature stop, ss) | Full | No | 10.1093/icb/icy004 |