Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GPRC5C G protein-coupled receptor class C group 5 member C	RAIG3 , RAIG-3	Homo sapiens	7	protein-coding	GPRC5D , GPRC5A , GPRC5B		605949

Summary

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0004930	enables G protein-coupled receptor activity	IEA

Component (8)

Go ID	Value	Evidence
0030659	located_in cytoplasmic vesicle membrane	IEA
0070062	located_in extracellular exosome	HDA
0070062	is_active_in extracellular exosome	IBA
0043231	is_active_in intracellular membrane-bounded organelle	IBA
0005886	is_active_in plasma membrane	IBA
0043235	part_of receptor complex	IBA
0043235	part_of receptor complex	IDA
0031982	located_in vesicle	HDA

Process (1)

Go ID	Value	Evidence
0007186	involved_in G protein-coupled receptor signaling pathway	IEA

Gene Loss events - GPRC5C (1 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_FKKGBH	Rousettus aegyptiacus	Chiroptera	LOF (frameshift, premature stop, ss)	Full	No	10.1093/icb/icy004