Reference Gene

Gene name Alias Species Exons Type Paralogs EC number OMIM
SIX3 SIX homeobox 3 HPE2 Homo sapiens 2 protein-coding SIX6 , SIX5 , SIX4 , SIX2 , ANHX , SIX1 603714

Summary

This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]

GeneOntology

Gene Loss events - SIX3 (2 results)

GL_ID Species Order Gene Loss Mechanism Loss Type Lineage Specific Citation
GL_3OH7ME Dasypus novemcinctus Cingulata Gene deletion Full No 10.1093/icb/icy004
GL_PQSNPH Carlito syrichta Primates Gene deletion Full No 10.1093/icb/icy004