Gene Loss

Reference Gene

Gene name	Alias	Species	Exons	Type	Paralogs	EC number	OMIM
GRK1 G protein-coupled receptor kinase 1	RK , RHOK , GPRK1	Homo sapiens	8	protein-coding	RSKR , GRK7 , GRK6 , GRK4 , GRK5 , GRK2 , GRK3	2.7.11.14	180381

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]

GeneOntology

Function (1)

Go ID	Value	Evidence
0005524	enables ATP binding	IEA

Component (2)

Go ID	Value	Evidence
0005737	is_active_in cytoplasm	IBA
0097381	located_in photoreceptor disc membrane	TAS

Process (7)

Go ID	Value	Evidence
0016056	involved_in G protein-coupled opsin signaling pathway	TAS
0046777	involved_in protein autophosphorylation	IMP
0008277	involved_in regulation of G protein-coupled receptor signaling pathway	TAS
0022400	involved_in regulation of opsin-mediated signaling pathway	IDA
0022400	involved_in regulation of opsin-mediated signaling pathway	TAS
0009966	involved_in regulation of signal transduction	IBA
0007601	involved_in visual perception	IEA

Gene Loss events - GRK1 (2 results)

GL_ID	Species	Order	Gene Loss Mechanism	Loss Type	Lineage Specific	Citation
GL_20B7ZC	Tupaia chinensis	Scandentia	Gene deletion	Full	No	10.1093/icb/icy004
GL_KQWQWZ	Condylura cristata	Eulipotyphla	Gene deletion	Full	No	10.1093/icb/icy004